A canine mastocytoma with oncogenic c-kit activation by intra-exonic alternative splicing
We report a subcutaneous mastocytoma in a mid-aged Italian greyhound dog with a small 41 bp genomic deletion of the c-kit gene leading to skipping of the authentic 3′-splice junction of intron 10.The shift to an alternative splice junction wella color charm 050 cooling violet in exon 11 leads to a mis-spliced in-frame mRNA transcript with a 27 bp